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¹⁵ N-Azides as practical and effective tags for developing long-lived hyperpolarized agents

https://doi.org/10.1039/D1SC04647K

Bae, Junu; Zhang, Guannan; Park, Hyejin; Warren, Warren S.; Wang, Qiu (November 2021, Chemical Science)

Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate ( 15 N) 3 -azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing ( 15 N) 3 -azide as a powerful spin storage for hyperpolarization. A single ( 15 N)-labeled azide has also been examined as an effective alternative tag with long-lived hyperpolarization. A variety of biologically important molecules are studied in this work, including choline, glucose, amino acid, and drug derivatives, demonstrating great potential of 15 N-labeled azides as universal hyperpolarized tags for nuclear magnetic resonance imaging applications.
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Application of ¹⁵ N ₂ -Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP

https://doi.org/10.1021/acs.bioconjchem.0c00028

Park, Hyejin; Zhang, Guannan; Bae, Junu; Theis, Thomas; Warren, Warren S.; Wang, Qiu (March 2020, Bioconjugate Chemistry)

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Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange

https://doi.org/10.1038/s41467-019-08298-8

Lindale, Jacob R.; Eriksson, Shannon L.; Tanner, Christian P.; Zhou, Zijian; Colell, Johannes F.; Zhang, Guannan; Bae, Junu; Chekmenev, Eduard Y.; Theis, Thomas; Warren, Warren S. (December 2019, Nature Communications)

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¹⁵ N ₄ -1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para -N ₂

https://doi.org/10.1126/sciadv.aar2978

Bae, Junu; Zhou, Zijian; Theis, Thomas; Warren, Warren S.; Wang, Qiu (March 2018, Science Advances)

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